This book is a novel contribution to academic discourses on the coronavirus (COVID-19) crisis and how it has impacted societies globally. It proffers an overview on the social development and political measures, from both the Global North and Global South, to prevent COVID-19's spread. It illuminates major social, political and economic challenges that already existed in different contexts and which are also currently being amplified by COVID-19. Curiously, this global pandemic has opened spaces for different actors, across the globe, to begin to fundamentally question and challenge the hegemony of the Global North, which sometimes is evident in social work. Linked to the foregoing and while reflecting beyond the pandemic and into the future, the book proposes that social work must become more political at all levels, and strive to transform societies, global social development efforts, and economic and health systems.